If baseline SBP was less than 140 mm Hg, the point estimate shifted towards an increased risk with treatment, albeit not statistically significant (relative risk 1.05, 95% confidence interval 0.95 to 1.16). The same trend was observed if attained SBP was less than 130 mm Hg. Both baseline and attained SBP significantly interacted with treatment effect on all cause mortality (P=0.019 and 0.009, respectively), indicating that the treatment effect is worse with lower SBP.Cardiovascular mortality was reduced if baseline SBP was more than 150 mm Hg.
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